The Black Death was the second plague pandemic which took place in the 14th century. The major symptoms of the plague were a severe general health condition, fever, lymph node, pulmonary, and other organs involvement, as well as sepsis. The main cause of the spread of bubonic plague was fleas living on rats.
The Black Death travelled to Europe from Africa, India, and China. It killed half of the European population. Later, there were several minor plague outbreaks on the territory of Europe.
Bubonic plague was completely defeated only in 1947 after the invention of streptomycin. The antibiotic was successfully tested during the outbreak of the plague in Manchuria.